Coverage-dependent bias creates the appearance of binary splicing in single cells

Coverage-dependent bias creates the appearance of binary splicing in single cells

Single-cell RNA sequencing provides powerful insight into the factors that determine each cell’s unique identity. Previous studies led to the surprising observation that alternative splicing among single cells is highly variable and follows a bimodal pattern: a given cell consistently produces eithe...

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Bibliographic Details
Main Authors: Carlos F Buen Abad Najar, Nir Yosef, Liana F Lareau
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
alternative splicing
scRNA-seq
single cell
Online Access:https://elifesciences.org/articles/54603

Internet

https://elifesciences.org/articles/54603

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