Absence of Nuclear p16 Is a Diagnostic and Independent Prognostic Biomarker in Squamous Cell Carcinoma of the Cervix

Absence of Nuclear p16 Is a Diagnostic and Independent Prognostic Biomarker in Squamous Cell Carcinoma of the Cervix

The tumor-suppressor protein p16 is paradoxically overexpressed in cervical cancer (CC). Despite its potential as a biomarker, its clinical value and the reasons for its failure in tumor suppression remain unclear. Our purpose was to determine p16 clinical and biological significance in CC. p16 expr...

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Bibliographic Details
Main Authors: Saioa Mendaza, Joaquín Fernández-Irigoyen, Enrique Santamaría, Tamara Zudaire, Rosa Guarch, David Guerrero-Setas, August Vidal, José Santos-Salas, Xavier Matias-Guiu, Karina Ausín, María José Díaz de Cerio, Esperanza Martín-Sánchez
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
cytoplasmic p16
nuclear p16
subcellular location
predictive biomarker
squamous cell carcinoma of the cervix
high-grade squamous intraepithelial lesion
cervical cancer
Online Access:https://www.mdpi.com/1422-0067/21/6/2125

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https://www.mdpi.com/1422-0067/21/6/2125

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