The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System

Arsenic trioxide (As2O3) has shown effectiveness in treatment of leukemia but is also associated with reproductive toxicity. Since remediation with N-acetylcysteine (NAC) may mitigate the adverse effects caused by exposure, we assessed the effects of As2O3 and its potential reversibility after expos...

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Main Authors: Raquel Frenedoso da Silva, Cibele dos Santos Borges, Patrícia Villela e Silva, Gabriela Missassi, Luiz Ricardo Almeida Kiguti, André Sampaio Pupo, Fernando Barbosa Junior, Janete Aparecida Anselmo-Franci, Wilma De Grava Kempinas
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2016/4257498