Effect of Acid‐Suppressive Strategies on Pazopanib Efficacy in Patients With Soft‐Tissue Sarcoma

Pazopanib (PAZ), a tyrosine kinase inhibitor used in the treatment of soft tissue sarcoma (STS), should not be administered with acid‐suppressive medications (ASMs) due to decreased drug solubility. Common practice for patients requiring ASM with PAZ is to separate administration by 12 hours; howeve...

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Bibliographic Details
Main Authors: Sorana G. Pisano, Sarah E. Hoffman, Carlo S. Legasto, Eric M. McLaughlin, Kyle Porter, James L. Chen
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.12648