Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

Emerging evidence indicate that the mammalian checkpoint kinase ATM induces transcriptional silencing in cis to DNA double-strand breaks (DSBs) through a poorly understood mechanism. Here we show that in Saccharomyces cerevisiae a single DSB causes transcriptional inhibition of proximal genes indepe...

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Bibliographic Details
Main Authors: Nicola Manfrini, Michela Clerici, Maxime Wery, Chiara Vittoria Colombo, Marc Descrimes, Antonin Morillon, Fabrizio d'Adda di Fagagna, Maria Pia Longhese
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
DNA double-strand break
resection
S. cerevisiae
transcription
RNA polymerase
Online Access:https://elifesciences.org/articles/08942

Internet

https://elifesciences.org/articles/08942

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