A Fixed-Dose Combination, QXOH/Levobupivacaine, Produces Long-Acting Local Anesthesia in Rats Without Additional Toxicity

A Fixed-Dose Combination, QXOH/Levobupivacaine, Produces Long-Acting Local Anesthesia in Rats Without Additional Toxicity

QXOH, a QX314 derivative with longer duration and lesser local toxicity, is a novel local anesthetic in preclinical drug development. Previous studies demonstrated that bupivacaine can prolong the effects of QX314. So, we attempted to combine QXOH with levobupivacaine to shorten the onset time and l...

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Bibliographic Details
Main Authors: Qinqin Yin, Yujun Zhang, Rong Lv, Deying Gong, Bowen Ke, Jun Yang, Lei Tang, Wensheng Zhang, Tao Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
QXOH
fixed-dose combination (FDC)
preclinical drug development
long-acting local anesthetic
local toxicity
systemic toxicity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00243/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00243/full

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