Structural Study of Metal Binding and Coordination in Ancient Metallo-β-Lactamase PNGM-1 Variants

Structural Study of Metal Binding and Coordination in Ancient Metallo-β-Lactamase PNGM-1 Variants

The increasing incidence of community- and hospital-acquired infections with multidrug-resistant (MDR) bacteria poses a critical threat to public health and the healthcare system. Although β-lactam antibiotics are effective against most bacterial infections, some bacteria are resistant to β-lactam a...

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Bibliographic Details
Main Authors: Yoon Sik Park, Tae Yeong Kim, Hyunjae Park, Jung Hun Lee, Diem Quynh Nguyen, Myoung-Ki Hong, Sang Hee Lee, Lin-Woo Kang
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
metallo-β-lactamase (MBL)
metal coordination
antibiotics
x-ray crystallography
Online Access:https://www.mdpi.com/1422-0067/21/14/4926

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https://www.mdpi.com/1422-0067/21/14/4926

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