Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels

Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels

Hepatitis C virus (HCV) substantially affects lipid metabolism, and remodeling of sphingolipids appears to be essential for HCV persistence in vitro. The aim of the current study is the evaluation of serum sphingolipid variations during acute HCV infection. We enrolled prospectively 60 consecutive p...

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Bibliographic Details
Main Authors: Georgios Grammatikos, Julia Dietz, Nerea Ferreiros, Alexander Koch, Georg Dultz, Dimitra Bon, Ioannis Karakasiliotis, Thomas Lutz, Gaby Knecht, Peter Gute, Eva Herrmann, Stefan Zeuzem, Penelope Mavromara, Christoph Sarrazin, Josef Pfeilschifter
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
HIV
hepatitis C
sphingolipid
biomarker
angiopoietin-like 3 (ANGPTL3)
Online Access:http://www.mdpi.com/1422-0067/17/6/922

Internet

http://www.mdpi.com/1422-0067/17/6/922

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