γ2 GABAAR Trafficking and the Consequences of Human Genetic Variation

GABA type A receptors (GABAARs) mediate the majority of fast inhibitory neurotransmission in the central nervous system (CNS). Most prevalent as heteropentamers composed of two α, two β, and a γ2 subunit, these ligand-gated ionotropic chloride channels are capable of extensive genetic diversity (α1-...

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Bibliographic Details
Main Authors: Joshua M. Lorenz-Guertin, Matthew J. Bambino, Tija C. Jacob
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00265/full