The subthalamic nucleus becomes a generator of bursts in the dopamine-depleted state. Its high frequency stimulation dramatically weakens transmission to the globus pallidus

The subthalamic nucleus becomes a generator of bursts in the dopamine-depleted state. Its high frequency stimulation dramatically weakens transmission to the globus pallidus

Excessive burst firing in the dopamine-depleted basal ganglia correlates with severe motor symptoms of Parkinson’s disease that are attenuated by high frequency electrical stimulation of the subthalamic nucleus. Here we test the hypothesis that pathological bursts in dopamine-deprived basal ganglia...

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Bibliographic Details
Main Authors: Rachida eAmmari, Bernard eBioulac, Liliana eGarcia, Constance eHammond
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-06-01
Series:Frontiers in Systems Neuroscience
Subjects:
Basal Ganglia
Subthalamic Nucleus
Parkinson
burst firing
basal ganglia slice
high frequency stimulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsys.2011.00043/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnsys.2011.00043/full

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