Iminosugars With Endoplasmic Reticulum α-Glucosidase Inhibitor Activity Inhibit ZIKV Replication and Reverse Cytopathogenicity in vitro

Iminosugars With Endoplasmic Reticulum α-Glucosidase Inhibitor Activity Inhibit ZIKV Replication and Reverse Cytopathogenicity in vitro

Zika virus (ZIKV), a vector-borne virus of the family Flaviviridae, continues to spread and remains a significant global public health threat. Currently, there are no approved vaccines or antivirals against ZIKV. We investigated the anti-ZIKV ability of three iminosugars with endoplasmic reticulum α...

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Bibliographic Details
Main Authors: Gitanjali Bhushan, Levina Lim, Ian Bird, Shubhada K. Chothe, Ruth H. Nissly, Suresh V. Kuchipudi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Microbiology
Subjects:
Zika virus
antiviral
iminosugar
ER-AGI
castanospermine
celgosivir
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00531/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00531/full

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