MicroRNA-21 (miR-21) Post-Transcriptionally Downregulates Tumor Suppressor PDCD4 and Promotes Cell Transformation, Proliferation, and Metastasis in Renal Cell Carcinoma

MicroRNA-21 (miR-21) Post-Transcriptionally Downregulates Tumor Suppressor PDCD4 and Promotes Cell Transformation, Proliferation, and Metastasis in Renal Cell Carcinoma

Objectives: MiR-21 induces neoplastic transformation, cell proliferation, and metastasis and downregulates programmed cell death4 (PDCD4) in some cancers. The aim of this study was to investigate the roles and interactions of PDCD4 and miR-21 in human renal cell carcinoma (RCC). Materials and Method...

Full description

Bibliographic Details
Main Authors: Xiancheng Li, Shiyong Xin, Zhongzhou He, Xiangyu Che, Jianbo Wang, Xiaoguang Xiao, Jie Chen, Xishuang Song
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
MiR-21
RCC
EDU
PDCD4
Metastasis
Online Access:http://www.karger.com/Article/FullText/362946

Internet

http://www.karger.com/Article/FullText/362946

Similar Items