Quantifying the Evolutionary Constraints and Potential of Hepatitis C Virus NS5A Protein

Many viruses adapt rapidly to novel selection pressures, such as antiviral drugs. Understanding how pathogens evolve under drug selection is critical for the success of antiviral therapy against human pathogens.

Bibliographic Details
Main Authors: Lei Dai, Yushen Du, Hangfei Qi, Christian D. Huber, Dongdong Chen, Tian-Hao Zhang, Nicholas C. Wu, Ergang Wang, James O. Lloyd-Smith, Ren Sun
Format: Article
Language:English
Published: American Society for Microbiology 2021-04-01
Series:mSystems
Online Access:https://journals.asm.org/doi/10.1128/mSystems.01111-20