Search for Non-Protein Protease Inhibitors Constituted with an Indole and Acetylene Core

Search for Non-Protein Protease Inhibitors Constituted with an Indole and Acetylene Core

A possible inhibitor of proteases, which contains an indole core and an aromatic polar acetylene, was designed and synthesized. This indole derivative has a molecular architecture kindred to biologically relevant species and was obtained through five synthetic steps with an overall yield of 37% from...

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Bibliographic Details
Main Authors: Marco A. Almaraz-Girón, Ernesto Calderón-Jaimes, Adrián Sánchez Carrillo, Erik Díaz-Cervantes, Edith Castañón Alonso, Alejandro Islas-Jácome, Armando Domínguez-Ortiz, Sandra L. Castañón-Alonso
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
synthesis
indole derivatives
inhibitor of proteases
studies <i>in silico</i>
docking studies
SARS-CoV-2-M<sup>pro</sup>
Online Access:https://www.mdpi.com/1420-3049/26/13/3817

Internet

https://www.mdpi.com/1420-3049/26/13/3817

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