IC100: a novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis

IC100: a novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis

Abstract Background The inflammasome adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is involved in immune signaling by bridging the interactions between inflammasome sensors and caspase-1. Strong experimental evidence has shown that ASC−/− mice are protected from disease pro...

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Bibliographic Details
Main Authors: Haritha L. Desu, Melanie Plastini, Placido Illiano, Helen M. Bramlett, W. Dalton Dietrich, Juan Pablo de Rivero Vaccari, Roberta Brambilla, Robert W. Keane
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Neuroinflammation
Subjects:
IC100
Inflammasome
Neuroinflammation
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Caspase-1
Online Access:http://link.springer.com/article/10.1186/s12974-020-01826-0

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http://link.springer.com/article/10.1186/s12974-020-01826-0

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