TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2

TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2

Abstract Tripartite motif (TRIM) family proteins are important effectors of innate immunity against viral infections. Here we identified TRIM35 as a regulator of TRAF3 activation. Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon (IFN) in response to viral infectio...

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Bibliographic Details
Main Authors: Nan Sun, Li Jiang, Miaomiao Ye, Yihan Wang, Guangwen Wang, Xiaopeng Wan, Yuhui Zhao, Xia Wen, Libin Liang, Shujie Ma, Liling Liu, Zhigao Bu, Hualan Chen, Chengjun Li
Format: Article
Language:English
Published: SpringerOpen 2020-06-01
Series:Protein & Cell
Subjects:
influenza A virus
PB2
TRIM35
TRAF3
ubiquitination
antiviral immunity
Online Access:https://doi.org/10.1007/s13238-020-00734-6

Internet

https://doi.org/10.1007/s13238-020-00734-6

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