Activation of DNA Damage Tolerance Pathways May Improve Immunotherapy of Mesothelioma

Activation of DNA Damage Tolerance Pathways May Improve Immunotherapy of Mesothelioma

Immunotherapy based on two checkpoint inhibitors (ICI), programmed cell death 1 (PD-1, Nivolumab) and cytotoxic T-lymphocyte 4 (CTLA-4, Ipilimumab), has provided a significant improvement in overall survival for malignant mesothelioma (MM). Despite this major breakthrough, the median overall surviva...

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Bibliographic Details
Main Authors: Hélène Brossel, Alexis Fontaine, Clotilde Hoyos, Majeed Jamakhani, Mégane Willems, Malik Hamaidia, Luc Willems
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
mesothelioma
tolerance to DNA damage
DNA damage response
chemoresistance
immunotherapy
immune checkpoint inhibitor
Online Access:https://www.mdpi.com/2072-6694/13/13/3211

Internet

https://www.mdpi.com/2072-6694/13/13/3211

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