Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs

Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs

Ceftiofur (CEF) sodium is a third-generation broad-spectrum cephalosporin commonly used in an extra-label manner in dogs for the treatment of respiratory and urinary system infections. To contribute to the literature supporting CEF use in companion animals, we have developed a compartmental, non-lin...

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Bibliographic Details
Main Authors: Jianzhong Wang, Benjamin K. Schneider, Jiao Xue, Pan Sun, Jicheng Qiu, Jonathan P. Mochel, Xingyuan Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Veterinary Science
Subjects:
ceftiofur sodium
pharmacokinetics
NLME
monte carlo simulations
dogs
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2019.00363/full

Internet

https://www.frontiersin.org/article/10.3389/fvets.2019.00363/full

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