Sphingomyelinases D From Loxosceles Spider Venoms and Cell Membranes: Action on Lipid Rafts and Activation of Endogenous Metalloproteinases

Sphingomyelinases D From Loxosceles Spider Venoms and Cell Membranes: Action on Lipid Rafts and Activation of Endogenous Metalloproteinases

Loxosceles spider venom contains Sphingomyelinase D (SMase D), the key toxin causing pathology. SMase D hydrolyzes the main component of lipid rafts, sphingomyelin, which changes the membrane microenvironment resulting in the activation of endogenous metalloproteinase from the ADAMs family. Alterati...

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Bibliographic Details
Main Authors: Priscila Hess Lopes, Carmen W. van den Berg, Denise V. Tambourgi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
lipid rafts
Loxosceles
Sphingomyelinases D
ADAMs
proprotein convertases
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00636/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00636/full

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