Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins

Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins

High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient autoimmune regulator (AIRE) gene collectively display a broad repertoire of high titer autoantibodies, including some which are pathognomonic for m...

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Bibliographic Details
Main Authors: Dmytro Fishman, Kai Kisand, Christina Hertel, Mike Rothe, Anu Remm, Maire Pihlap, Priit Adler, Jaak Vilo, Aleksandr Peet, Antonella Meloni, Katarina Trebusak Podkrajsek, Tadej Battelino, Øyvind Bruserud, Anette S. B. Wolff, Eystein S. Husebye, Nicolas Kluger, Kai Krohn, Annamari Ranki, Hedi Peterson, Adrian Hayday, Pärt Peterson
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
autoimmune regulator
autoantibodies
immune tolerance
thymus
autoantigen
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00976/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00976/full

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