Immunization With a DNA Vaccine Cocktail Encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 Genes Protects Mice Against Chronic Toxoplasmosis

Immunization With a DNA Vaccine Cocktail Encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 Genes Protects Mice Against Chronic Toxoplasmosis

Toxoplasmosis is a zoonotic disease caused by the intracellular protozoan Toxoplasma gondii; and a major source of infection in humans is via ingestion of T. gondii tissue cysts. Ultimately, the goal of anti-toxoplasmosis vaccines is to elicit a sustainable immune response, capable of preventing for...

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Bibliographic Details
Main Authors: Nian-Zhang Zhang, Qi Gao, Meng Wang, Hany M. Elsheikha, Bo Wang, Jin-Lei Wang, Fu-Kai Zhang, Ling-Ying Hu, Xing-Quan Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
Toxoplasma gondii
chronic toxoplasmosis
cocktail DNA vaccine
multistage antigens
mixed Th1/Th2 immune response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01505/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01505/full

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