TGFβ depletion does neither modulate acute E. coli-induced inflammatory immune responses nor impair the protective effect by chronic filarial infection

TGFβ depletion does neither modulate acute E. coli-induced inflammatory immune responses nor impair the protective effect by chronic filarial infection

TGFβ is an anti-inflammatory molecule that suppresses pro-inflammatory immune responses. Previously, we demonstrated that chronic filarial infection has a beneficial impact on -induced sepsis. In the present study, we investigated whether this protective effect is dependent on TGFβ signaling and whe...

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Bibliographic Details
Main Authors: Buerfent, Benedikt C., Ajendra, Jesuthas, Stamminger, Wiebke, Gondorf, Fabian, Hoerauf, Achim, Hübner, Marc P.
Format: Article
Language:English
Published: German Medical Science GMS Publishing House 2019-11-01
Series:GMS Infectious Diseases
Subjects:
tgf beta
sepsis
e. coli
immune modulation
systemic pro-inflammatory response syndrome (sirs)
litomosoides sigmodontis
helminth
filaria
nematode
Online Access:http://www.egms.de/static/en/journals/id/2019-7/id000044.shtml

Internet

http://www.egms.de/static/en/journals/id/2019-7/id000044.shtml

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