Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease

Abstract Background Alzheimer’s disease is a progressive neurodegenerative disorder that is hypothesized to involve epigenetic dysfunction. Previous studies of DNA modifications in Alzheimer’s disease have been unable to distinguish between DNA methylation and DNA hydroxymethylation. DNA hydroxymeth...

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Bibliographic Details
Main Authors: Adam R. Smith, Rebecca G. Smith, Ehsan Pishva, Eilis Hannon, Janou A. Y. Roubroeks, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Carolyn Sloan, Jonathan Mill, Daniel L. van den Hove, Katie Lunnon
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Clinical Epigenetics
Subjects:
Alzheimer’s disease (AD)
Brain
Ankyrin 1 (ANK1)
DNA methylation (5mC)
DNA hydroxymethylation (5hmC)
Entorhinal cortex (EC)
Online Access:http://link.springer.com/article/10.1186/s13148-019-0636-y

Internet

http://link.springer.com/article/10.1186/s13148-019-0636-y

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