Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events

Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events

Thrombosis is the main outcome of many cardiovascular diseases. Current treatments to prevent thrombotic events involve the long-term use of antiplatelet drugs. However, this therapy has several limitations, thereby justifying the development of new drugs. A series of N-oxide derivatives (furoxan an...

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Bibliographic Details
Main Authors: Leandro Augusto Rosseto, Maria Elisa Lopes Pires, Aylime Castanho Bolognesi Melchior, Priscila Longhin Bosquesi, Aline Renata Pavan, Sisi Marcondes, Man Chin Chung, Jean Leandro dos Santos
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Molecules
Subjects:
N-oxide
atherothrombosis
antiplatelet activity
bleeding time
furoxan
benzofuroxan
genotoxicity
Online Access:http://www.mdpi.com/1420-3049/20/10/18185

Internet

http://www.mdpi.com/1420-3049/20/10/18185

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