Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure

Frequency and Evolution of Azole Resistance in Aspergillus fumigatus Associated with Treatment Failure

Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been reported infrequently. The first resistant isolate was detected in 1999 in Manchester, UK. In a clinical collection of 519 A. fumigatus isolates, the frequency of itraconazole resistance was 5%, a sig...

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Bibliographic Details
Main Authors: Susan J. Howard, Dasa Cerar, Michael J. Anderson, Ahmed Albarrag, Matthew C. Fisher, Alessandro C. Pasqualotto, Michel Laverdiere, Maiken C. Arendrup, David S. Perlin, David W. Denning
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2009-07-01
Series:Emerging Infectious Diseases
Subjects:
Aspergillus fumigatus
azoles
antifungal drug resistance
sterol 14-alpha demethylase CYP51A
Aspergillus
population genetics
Online Access:https://wwwnc.cdc.gov/eid/article/15/7/09-0043_article

Internet

https://wwwnc.cdc.gov/eid/article/15/7/09-0043_article

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