The NFκB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases

The NFκB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases

Proinflammatory response and mitochondrial dysfunction are related to the pathogenesis of neurodegenerative diseases (NDs). Nuclear factor κB (NFκB) activation has been shown to exaggerate proinflammation and mitochondrial dysfunction, which underlies NDs. CDGSH iron-sulfur domain 2 (CISD2) has been...

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Bibliographic Details
Main Authors: Woon-Man Kung, Muh-Shi Lin
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
neurodegenerative disease
CISD2
proinflammatory response
mitochondrial dysfunction
NFκB
Online Access:https://www.mdpi.com/1422-0067/22/2/934

Internet

https://www.mdpi.com/1422-0067/22/2/934

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