Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a

Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a

DNA methylation is a central epigenetic modification that is established by de novo DNA methyltransferases. The mechanisms underlying the generation of genomic methylation patterns are still poorly understood. Using mass spectrometry and a phosphospecific Dnmt3a antibody, we demonstrate that CK2 pho...

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Bibliographic Details
Main Authors: Rachel Deplus, Loïc Blanchon, Arumugam Rajavelu, Abdelhalim Boukaba, Matthieu Defrance, Judith Luciani, Françoise Rothé, Sarah Dedeurwaerder, Hélène Denis, Arie B. Brinkman, Femke Simmer, Fabian Müller, Benjamin Bertin, Maria Berdasco, Pascale Putmans, Emilie Calonne, David W. Litchfield, Yvan de Launoit, Tomasz P. Jurkowski, Hendrik G. Stunnenberg, Christoph Bock, Christos Sotiriou, Mario F. Fraga, Manel Esteller, Albert Jeltsch, François Fuks
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714005324

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http://www.sciencedirect.com/science/article/pii/S2211124714005324

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