The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motoneurons and degradation of the neuromuscular junctions (NMJ). Consistent with the dying-back hypothesis of motoneuron degeneration the decline in synaptic function initiates from the presynaptic terminals in ALS. Oxi...

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Bibliographic Details
Main Authors: Eveliina ePollari, Gundars eGoldsteins, Genevieve eBart, Jari eKoistinaho, Rashid eGiniatullin
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neuromuscular Junction
Oxidative Stress
neurodegeneration
ALS
ROS (Reactive oxygen species)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00131/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00131/full

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