Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes

Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes

Fibroblast growth factor-1 (FGF-1) is secreted by astrocytes and stimulates apolipoprotein E (apoE)-HDL biogenesis by an autocrine mechanism to help in recovery from brain injury. In apoE-deficient mouse astrocytes, FGF-1 stimulated cholesterol biosynthesis without enhancing its release, indicating...

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Bibliographic Details
Main Authors: Jin-ichi Ito, Yuko Nagayasu, Kuniko Okumura-Noji, Rui Lu, Tomo Nishida, Yutaka Miura, Kiyofumi Asai, Alireza Kheirollah, Seiichi Nakaya, Shinji Yokoyama
Format: Article
Language:English
Published: Elsevier 2007-09-01
Series:Journal of Lipid Research
Subjects:
astrocytes
apolipoprotein E-high density lipoprotein
PI3K
Akt
MEK
ERK
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520424897

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520424897

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