In Vivo Attenuation of Antibody-Mediated Acute Renal Allograft Rejection by Ex Vivo TGF-β-Induced CD4+Foxp3+ Regulatory T Cells

In Vivo Attenuation of Antibody-Mediated Acute Renal Allograft Rejection by Ex Vivo TGF-β-Induced CD4+Foxp3+ Regulatory T Cells

Antibody-mediated rejection (AMR) has emerged as the major cause of renal allograft dysfunction, and more effective strategies need to be explored for improving transplant outcomes. Regulatory T cells (Tregs), consisting of at least natural and induced Treg subsets, suppress effector responses at mu...

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Bibliographic Details
Main Authors: Tao Liao, Youqiu Xue, Daqiang Zhao, Siwen Li, Mingyu Liu, Jingrong Chen, David Douglass Brand, Haofeng Zheng, Yannan Zhang, Song Guo Zheng, Qiquan Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
antibody-mediated rejection
renal transplantation
regulatory T cell
TGF-β
macrophages
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01334/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01334/full

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