Type-I Interferons Inhibit Interleukin-10 Signaling and Favor Type 1 Diabetes Development in Nonobese Diabetic Mice

Type-I Interferons Inhibit Interleukin-10 Signaling and Favor Type 1 Diabetes Development in Nonobese Diabetic Mice

Destruction of insulin-producing β-cells by autoreactive T lymphocytes leads to the development of type 1 diabetes. Type-I interferons (TI-IFN) and interleukin-10 (IL-10) have been connected with the pathophysiology of this disease; however, their interplay in the modulation of diabetogenic T cells...

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Bibliographic Details
Main Authors: Marcos Iglesias, Anirudh Arun, Maria Chicco, Brandon Lam, C. Conover Talbot, Vera Ivanova, W. P. A. Lee, Gerald Brandacher, Giorgio Raimondi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
type-I interferons
interleukin-10 signaling
T lymphocytes
type 1 diabetes
nonobese diabetic mice
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01565/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01565/full

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