High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway

High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway

Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear. This study investigated the regulatory role of Smad3, ezrin, and protein kinase A (PKA) in NADPH oxida...

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Bibliographic Details
Main Authors: Wanxu Guo, Hang Gao, Wei Pan, Panapn Yu, Guanghua Che
Format: Article
Language:English
Published: The Company of Biologists 2021-05-01
Series:Biology Open
Subjects:
podocyte apoptosis
high glucose
nox4
ezrin
pka
smad3
Online Access:http://bio.biologists.org/content/10/5/bio055012

Internet

http://bio.biologists.org/content/10/5/bio055012

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