Antibiotic Treatment Shapes the Antigenic Environment During Chronic TB Infection, Offering Novel Targets for Therapeutic Vaccination

Antibiotic Treatment Shapes the Antigenic Environment During Chronic TB Infection, Offering Novel Targets for Therapeutic Vaccination

The lengthy and complicated current regimen required to treat drug-susceptible tuberculosis (TB) reflects the ability of Mycobacterium tuberculosis (Mtb) to persist in host tissues. The stringent response pathway, governed by the dual (p)ppGpp synthetase/hydrolase, RelMtb, is a major mechanism under...

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Bibliographic Details
Main Authors: Yu-Min Chuang, Noton K. Dutta, James T. Gordy, Victoria L. Campodónico, Michael L. Pinn, Richard B. Markham, Chien-Fu Hung, Petros C. Karakousis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
tuberculosis DNA vaccines
persistence
stringent response
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00680/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00680/full

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