A Triple-Regulated Oncolytic Adenovirus Carrying MicroRNA-143 Exhibits Potent Antitumor Efficacy in Colorectal Cancer

A Triple-Regulated Oncolytic Adenovirus Carrying MicroRNA-143 Exhibits Potent Antitumor Efficacy in Colorectal Cancer

The cancer-targeting gene virotherapy might be a useful strategy for the treatment of cancer, because it could combine the advantages of both gene therapy and virotherapy. This study aimed to construct a triple-regulated oncolytic adenovirus, Ad-RGD-Survivin-ZD55-miR-143, carrying the therapeutic ge...

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Bibliographic Details
Main Authors: Qifeng Luo, Hongming Song, Xiaochong Deng, Jiayi Li, Wei Jian, Junyong Zhao, Xueyu Zheng, Shiva Basnet, Haiyan Ge, Twingle Daniel, Bin Xu, Lin Fang
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300139

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http://www.sciencedirect.com/science/article/pii/S2372770520300139

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