Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal AdenocarcinomaSummary

Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal AdenocarcinomaSummary

Background & Aims: Although nearly half of pancreatic ductal adenocarcinoma (PDAC) patients have diabetes mellitus with episodes of hyperglycemia, its tumor microenvironment is hypoglycemic. Thus, it is crucial for PDAC cells to develop adaptive mechanisms dealing with oscillating glucose levels...

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Bibliographic Details
Main Authors: Ziying Jian, Tao Cheng, Zhiheng Zhang, Susanne Raulefs, Kuangyu Shi, Katja Steiger, Nadja Maeritz, Karin Kleigrewe, Thomas Hofmann, Simone Benitz, Philipp Bruns, Daniel Lamp, Martin Jastroch, Jan Akkan, Carsten Jäger, Peilin Huang, Shuang Nie, Shanshan Shen, Xiaoping Zou, Güralp O. Ceyhan, Christoph W. Michalski, Helmut Friess, Jörg Kleeff, Bo Kong
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X18301061

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http://www.sciencedirect.com/science/article/pii/S2352345X18301061

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