High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells

High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells

<p>Abstract</p> <p>Background</p> <p>Clevudine is a nucleoside analog reverse transcriptase inhibitor that exhibits potent antiviral activity against hepatitis B virus (HBV) without serious side effects. However, mitochondrial myopathy has been observed in patients with...

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Bibliographic Details
Main Authors: Jang Yoon-Ok, Quan Xianglan, Das Ranjan, Xu Shanhua, Chung Choon-Hee, Ahn Chan Mug, Baik Soon-Koo, Kong In Deok, Park Kyu-Sang, Kim Moon Young
Format: Article
Language:English
Published: BMC 2012-01-01
Series:BMC Gastroenterology
Subjects:
clevudine
mitochondrial DNA
mitochondrial dysfunction
glucose-stimulated insulin secretion
Online Access:http://www.biomedcentral.com/1471-230X/12/4

Internet

http://www.biomedcentral.com/1471-230X/12/4

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