Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung, response to CSF-1R blockade and nanoparticle dr...

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Bibliographic Details
Main Authors: Michael F. Cuccarese, J. Matthew Dubach, Christina Pfirschke, Camilla Engblom, Christopher Garris, Miles A. Miller, Mikael J. Pittet, Ralph Weissleder
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14293