ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System

ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System

Activation of transcription factor NF-κB is a hallmark of infection with the gastric pathogen Helicobacter pylori, associated with inflammation and carcinogenesis. Genome-wide RNAi screening revealed numerous host factors involved in H. pylori-, but not IL-1β- and TNF-α-dependent NF-κB regulation. P...

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Bibliographic Details
Main Authors: Stephanie Zimmermann, Lennart Pfannkuch, Munir A. Al-Zeer, Sina Bartfeld, Manuel Koch, Jianping Liu, Cindy Rechner, Meike Soerensen, Olga Sokolova, Alla Zamyatina, Paul Kosma, André P. Mäurer, Frithjof Glowinski, Klaus-Peter Pleissner, Monika Schmid, Volker Brinkmann, Alexander Karlas, Michael Naumann, Marion Rother, Nikolaus Machuy, Thomas F. Meyer
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
NF-κB signaling
genome-wide RNAi screen
inflammation
pathogen-associated molecular pattern
PAMP
D-glycero-β-D-manno-heptose 1,7-bisphosphate
HBP
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311464

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http://www.sciencedirect.com/science/article/pii/S2211124717311464

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