The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis

The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis

Abstract Background Previous work from our laboratory has demonstrated that during acute viral brain infection, glial cells modulate antiviral T cell effector responses through the PD-1: PD-L1 pathway, thereby limiting the deleterious consequences of unrestrained neuroinflammation. Here, we evaluate...

Full description

Bibliographic Details
Main Authors: Sujata Prasad, Shuxian Hu, Wen S. Sheng, Priyanka Chauhan, Amar Singh, James R. Lokensgard
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Neuroinflammation
Subjects:
MCMV Infection
Acute Viral Infection
Acute Viral Encephalitis
Murine Brain Tissue
KLRG1 Expression
Online Access:http://link.springer.com/article/10.1186/s12974-017-0860-3

Internet

http://link.springer.com/article/10.1186/s12974-017-0860-3

Similar Items