The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide

The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide

The activation of microglia is decisively involved with the neurodegeneration observed in many neuroinflammatory pathologies, such as multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease. Tectorigenin (TEC) is an isoflavone isolated from various medicinal plants, such as Pueraria thunber...

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Bibliographic Details
Main Authors: Hye-Sun Lim, Yu Jin Kim, Bu-Yeo Kim, Gunhyuk Park, Soo-Jin Jeong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
tectorigenin
neuroinflammation
microglia
mitogen-activated protein kinases
nuclear factor-κB
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00462/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00462/full

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