Sequencing of Linkage Region on Chromosome 12p11 Identifies PKP2 as a Candidate Gene for Left Ventricular Mass in Dominican Families

Sequencing of Linkage Region on Chromosome 12p11 Identifies PKP2 as a Candidate Gene for Left Ventricular Mass in Dominican Families

Increased left ventricular mass (LVM) is an intermediate phenotype for cardiovascular disease (CVD) and a predictor of stroke. Using families from the Dominican Republic, we have previously shown LVM to be heritable and found evidence for linkage to chromosome 12p11. Our current study aimed to furth...

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Bibliographic Details
Main Authors: Nicole D. Dueker, Shengru Guo, Ashley Beecham, Liyong Wang, Susan H. Blanton, Marco R. Di Tullio, Tatjana Rundek, Ralph L. Sacco
Format: Article
Language:English
Published: Oxford University Press 2018-02-01
Series:G3: Genes, Genomes, Genetics
Subjects:
rare variants
DNA sequencing
left ventricle
plakophilin
Hispanics
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.300358

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.300358

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