The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model

The S Genome Segment Is Sufficient to Maintain Pathogenicity in Intra-Clade Lassa Virus Reassortants in a Guinea Pig Model

Genome reassortment in Lassa virus (LASV) has been reported in nature, but phenotypic consequences of this phenomenon are not well described. Here we characterize, both in vitro and in vivo, reassortment between 2 LASV strains: the prototypic 1976 Josiah strain and a more recently isolated 2015 Libe...

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Bibliographic Details
Main Authors: Stephen R. Welch, Florine E. M. Scholte, César G. Albariño, Markus H. Kainulainen, JoAnn D. Coleman-McCray, Lisa Wiggleton Guerrero, Ayan K. Chakrabarti, John D. Klena, Stuart T. Nichol, Jessica R. Spengler, Christina F. Spiropoulou
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Lassa virus
hemorrhagic fever
reassortment
guinea pig
reverse genetics
virus rescue
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00240/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00240/full

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