Epigenetic Changes Governing <i>Scn5a</i> Expression in Denervated Skeletal Muscle

Epigenetic Changes Governing <i>Scn5a</i> Expression in Denervated Skeletal Muscle

The <i>SCN5A</i> gene encodes the α-subunit of the voltage-gated cardiac sodium channel (Na<sub>V</sub>1.5), a key player in cardiac action potential depolarization. Genetic variants in protein-coding regions of the human <i>SCN5A</i> have been largely associated...

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Bibliographic Details
Main Authors: David Carreras, Rebecca Martinez-Moreno, Mel·lina Pinsach-Abuin, Manel M. Santafe, Pol Gomà, Ramon Brugada, Fabiana S. Scornik, Guillermo J. Pérez, Sara Pagans
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
cardiac arrhythmias
<i>Scn5a</i>
transcriptional regulation
epigenetic mechanisms
skeletal muscle denervation
histone modifications
Online Access:https://www.mdpi.com/1422-0067/22/5/2755

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https://www.mdpi.com/1422-0067/22/5/2755

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