Novel CD37, Humanized CD37 and Bi-Specific Humanized CD37-CD19 CAR-T Cells Specifically Target Lymphoma

Novel CD37, Humanized CD37 and Bi-Specific Humanized CD37-CD19 CAR-T Cells Specifically Target Lymphoma

CD19 and CD37 proteins are highly expressed in B-cell lymphoma and have been successfully targeted with different monotherapies, including chimeric antigen receptor (CAR)-T cell therapy. The goal of this study was to target lymphoma with novel CD37, humanized CD37, and bi-specific humanized CD37-CD1...

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Bibliographic Details
Main Authors: Vita Golubovskaya, Hua Zhou, Feng Li, Michael Valentine, Jinying Sun, Robert Berahovich, Shirley Xu, Milton Quintanilla, Man Cheong Ma, John Sienkiewicz, Yanwei Huang, Lijun Wu
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
chimeric antigen receptor
CAR-T cells
CD37
CD19
immunotherapy
cell therapy
Online Access:https://www.mdpi.com/2072-6694/13/5/981

Internet

https://www.mdpi.com/2072-6694/13/5/981

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