H-Ras Exerts Opposing Effects on Type I Interferon Responses Depending on Its Activation Status

H-Ras Exerts Opposing Effects on Type I Interferon Responses Depending on Its Activation Status

Using shRNA high-throughput screening, we identified H-Ras as a regulator of antiviral activity, whose depletion could enhance Sindbis virus replication. Further analyses indicated that depletion of H-Ras results in a robust increase in vesicular stomatitis virus infection and a decrease in Sendai v...

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Bibliographic Details
Main Authors: Guann-An Chen, Yun-Ru Lin, Hai-Ting Chung, Lih-Hwa Hwang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
H-Ras
type I interferon
retinoic acid-inducible gene-I-like receptor
MAVS signalosome
antiviral immunity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00972/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00972/full

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