Serotonin concentration enhancers at clinically relevant doses reduce [11C]AZ10419369 binding to the 5-HT1B receptors in the nonhuman primate brain

Serotonin concentration enhancers at clinically relevant doses reduce [11C]AZ10419369 binding to the 5-HT1B receptors in the nonhuman primate brain

Abstract The serotonin (5-HT) system plays an important role in the pathophysiology and treatment of several major psychiatric disorders. Currently, no suitable positron emission tomography (PET) imaging paradigm is available to assess 5-HT release in the living human brain. [11C]AZ10419369 binds to...

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Bibliographic Details
Main Authors: Kai-Chun Yang, Akihiro Takano, Christer Halldin, Lars Farde, Sjoerd J. Finnema
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-018-0178-7

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https://doi.org/10.1038/s41398-018-0178-7

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