Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes

Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes

Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus entry complex, which affected cellular tropism, viru...

Full description

Bibliographic Details
Main Authors: Joshua G. Tweedy, Eric Escriva, Maya Topf, Ursula A. Gompels
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Viruses
Subjects:
human herpesvirus
HHV-6
HHV-6A
Roseolovirus
betaherpesvirus
virus entry complex
gH/gL
gB
deep sequencing
reference genome
cell fusion
glycoprotein structure model
Online Access:https://www.mdpi.com/1999-4915/10/1/16

Internet

https://www.mdpi.com/1999-4915/10/1/16

Similar Items