Immunomodulatory Properties of Leishmania Extracellular Vesicles During Host-Parasite Interaction: Differential Activation of TLRs and NF-κB Translocation by Dermotropic and Viscerotropic Species

Immunomodulatory Properties of Leishmania Extracellular Vesicles During Host-Parasite Interaction: Differential Activation of TLRs and NF-κB Translocation by Dermotropic and Viscerotropic Species

Leishmania infection causes considerable human morbidity and may develop into a deadly visceral form in endemic regions. The parasite infects macrophages where they can replicate intracellularly. Furthermore, they modulate host immune responses by using virulence factors (lipophosphoglycan, glycopro...

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Bibliographic Details
Main Authors: Paula Monalisa Nogueira, Armando de Menezes-Neto, Valéria M. Borges, Albert Descoteaux, Ana Claudia Torrecilhas, Patrícia Xander, Or-Yam Revach, Neta Regev-Rudzki, Rodrigo Pedro Soares
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
extracellular vesicles
Leishmania
host-parasite interaction
innate immunity
lipophosphoglycan (LPG)
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00380/full

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https://www.frontiersin.org/article/10.3389/fcimb.2020.00380/full

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