BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation

BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation

ABSTRACT Background: Breast cancer is the neoplasm with both the highest incidence and mortality rate among women worldwide. Given the known snake venom cytotoxicity towards several tumor types, we evaluated the effects of BthTX-I from Bothrops jararacussu on MCF7, SKBR3, and MDAMB231 breast cancer...

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Bibliographic Details
Main Authors: Patrícia Heloise Alves Bezerra, Isadora Marques Ferreira, Beatriz Tinoco Franceschi, Francine Bianchini, Luciana Ambrósio, Adélia Cristina O. Cintra, Suely Vilela Sampaio, Fabíola Attié de Castro, Maria Regina Torqueti
Format: Article
Language:English
Published: SciELO
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
apoptosis
bothropstoxin
breast cancer
cancer stem cells
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100315&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100315&lng=en&tlng=en

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