Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1beta (PGC-1beta) has been implicated in important metabolic processes. A mouse lacking PGC-1beta (PGC1betaKO) was generated and phenotyped using physiological, molecular, and bioinformatic approaches. PGC1b...

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Bibliographic Details
Main Authors: Christopher J Lelliott, Gema Medina-Gomez, Natasa Petrovic, Adrienn Kis, Helena M Feldmann, Mikael Bjursell, Nadeene Parker, Keira Curtis, Mark Campbell, Ping Hu, Dongfang Zhang, Sheldon E Litwin, Vlad G Zaha, Kimberly T Fountain, Sihem Boudina, Mercedes Jimenez-Linan, Margaret Blount, Miguel Lopez, Aline Meirhaeghe, Mohammad Bohlooly-Y, Leonard Storlien, Maria Strömstedt, Michael Snaith, Matej Oresic, E Dale Abel, Barbara Cannon, Antonio Vidal-Puig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.0040369

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